| | Statistic | FOR | OPP |
| Total Yards per Game | 443.5 | 448.0 |
| Rushing YDS per ATT | 5.9 | 3.7 |
| Passing YDS per ATT | 8.0 | 8.6 |
| Passing Comp % | 0.661 | 0.667 |
| Total YDS per Play | 6.8 | 7.1 |
| Total YDS per Point | 14.1 | 13.2 |
|
| Injury |
| [DT] 09/19/2021 - Brandon Williams injured last game, is "?" Sunday vs Detroit ( Neck ) |
| [S] 09/19/2021 - DeShon Elliott left last game, is "?" Sunday vs Detroit ( Concussion ) |
| [T] 09/19/2021 - Ronnie Stanley is "?" Sunday vs Detroit ( Ankle ) |
| [DE] 09/19/2021 - Derek Wolfe is "?" Sunday vs Detroit ( Back ) |
| [CB] 09/19/2021 - Jimmy Smith is "?" Sunday vs Detroit ( Ankle ) |
| [DE] 09/19/2021 - Daelin Hayes is "?" Sunday vs Detroit ( Knee ) |
| [CB] 09/17/2021 - Chris Westry IR ( Knee ) |
| [G] 09/14/2021 - Tyre Phillips IR ( Undisclosed ) |
| [TE] 09/10/2021 - Nick Boyle IR ( Knee ) |
| [CB] 09/09/2021 - Marcus Peters IR; is out for season ( ACL ) |
| [RB] 09/09/2021 - Gus Edwards IR; is out for season ( ACL ) |
| [WR] 09/06/2021 - Miles Boykin IR ( Hamstring ) |
| [DT] 09/06/2021 - Aaron Crawford IR ( Undisclosed ) |
| [CB] 09/06/2021 - Khalil Dorsey IR ( Undisclosed ) |
| [LB] 09/06/2021 - L.J. Fort IR ( Knee ) |
| [LB] 09/06/2021 - Otaro Alaka IR ( Undisclosed ) |
| [DT] 09/06/2021 - Xavier Kelly IR ( Achilles ) |
| [RB] 09/06/2021 - Justice Hill IR ( Achilles ) |
| [RB] 08/29/2021 - J.K. Dobbins IR ( Knee ) |
| [WR] 08/12/2021 - Rashod Bateman IR ( Groin ) |
