| | Statistic | FOR | OPP |
| Total Yards per Game | 225.0 | 306.0 |
| Rushing YDS per ATT | 3.9 | 2.8 |
| Passing YDS per ATT | 5.4 | 6.6 |
| Passing Comp % | 0.605 | 0.630 |
| Total YDS per Play | 4.5 | 5.1 |
| Total YDS per Point | 10.0 | 21.1 |
|
| Injury |
| [DE] 09/24/2021 - Tanoh Kpassagnon is probable Sunday vs New England ( Calf ) |
| [LB] 09/24/2021 - Pete Werner is probable Sunday vs New England ( Hamstring ) |
| [CB] 09/24/2021 - Marshon Lattimore is probable Sunday vs New England ( Thumb ) |
| [S] 09/24/2021 - Chauncey Gardner-Johnson is probable Sunday vs New England ( Knee ) |
| [LB] 09/23/2021 - Chase Hansen IR ( Groin ) |
| [DE] 09/17/2021 - Marcus Davenport IR ( Pectoral ) |
| [LB] 09/17/2021 - Kwon Alexander IR ( Elbow ) |
| [OL] 09/16/2021 - Erik McCoy is out indefinitely ( Calf ) |
| [WR] 09/14/2021 - Michael Thomas IR ( Ankle ) |
| [WR] 09/10/2021 - Tre'quan Smith IR ( Hamstring ) |
| [CB] 09/10/2021 - Ken Crawley IR ( Hamstring ) |
| [K] 09/06/2021 - Wil Lutz IR ( Abdominal ) |
| [TE] 09/06/2021 - Nick Vannett IR ( Leg ) |
| [OL] 09/06/2021 - Ethan Greenidge IR ( Undisclosed ) |
| [DB] 09/06/2021 - Brian Poole IR ( Undisclosed ) |
| [TE] 09/06/2021 - Dylan Soehner IR ( Undisclosed ) |
| [DT] 09/06/2021 - Jalen Dalton IR ( Triceps ) |
| [C] 09/06/2021 - William Clapp IR ( Undisclosed ) |
